The effect of meloxicam on pain sensitivity, rumination time and clinical signs in dairy cows with endotoxin-induced clinical mastitis

The objectives of this study were (1), to evaluate the use of a
pressure algometer and an automated rumination monitoring
system to assess changes in pain sensitivity and rumination time
in response to endotoxin-induced clinical mastitis and (2) to
evaluate the effect of the nonsteroidal anti-inflammatory drug
meloxicam on pain sensitivity and rumination time, as well as
other clinical signs, in dairy cattle with endotoxin-induced
clinical mastitis. In control animals, the difference in the
pressure applied to the control and challenged quarters (control –
challenged quarter) increased by 1.1 kg +/- 0.4 kg of force 6
hours after infusion of lipopolysaccharide (LPS) compared with
the baseline, suggesting an increase in pain sensitivity in the
challenged quarter. Neither the LPS infusion nor the meloxicam
treatment had an effect on daily rumination time. However, the
rumination diurnal pattern on the day of LPS infusion showed
an overall deviation from the baseline pattern. Cows spent less
time ruminating in the hours following LPS infusion and more
time ruminating later in the day. Meloxicam did not alter
somatic cell score or dry matter intake. However, meloxicamtreated
animals had less udder edema and a lower body
temperature in the hours following LPS infusion compared with
control animals It was concluded that meloxicam has a
beneficial effect in relieving pain and decreasing udder edema
and body temperature in LPS-induced clinical mastitis.
Source: Fitzpatrick et al. – Journal of Dairy Science, 96, 2847-
2856, 2013
Complete abstract: www.m²-magazine/org > 033-